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Articles in PresS, published online ahead of print December 17, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00371.2002
Submitted on August 20, 2002
Accepted on December 11, 2002
1 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA
2 Department of Surgery, East Carolina University, Greenville, NC, USA; Diabetes/Obesity Center, East Carolina University, Greenville, NC, USA
3 Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA; Human Performance Laboratory, East Carolina University, Greenville, NC, USA; Diabetes/Obesity Center, East Carolina University, Greenville, NC, USA
* To whom correspondence should be addressed. E-mail: HOUMARDJ{at}MAIL.ECU.EDU.
The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals (BMI, 52.2 ±2.5 kg/m2, N=6)before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction (P<0.01) in BMI and a 93% decrease in HOMA (7.0 ± 1.9 vs 0.5 ± 0.1). Histochemically-determined IMCL content decreased (P<0.05) by ~30%. In relation to fiber type, IMCL was significantly higher in the type I vs type II fibers. In both fiber types there were reductions in IMCL and trends for muscle atrophy; despite these two negating factors, the IMCL/fiber area ratio still decreased by ~44% with weight loss. In conclusion, despite differing initial levels and possible atrophy, weight loss appears to decrease IMCL deposition to a similar relative extent in type I and II muscle fibers; this reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss.
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