| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print November 20, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00369.2001
Submitted on August 16, 2001
Accepted on November 14, 2001
1 Faculty of Medicine - Endocrinology, Memorial University, St. John's, NF, Canada
2 Department of Medicine, Austin & Repatriation Medical Center, University of Melbourne, Heidelberg West, Victoria, Australia
* To whom correspondence should be addressed. E-mail: ckovacs{at}mun.ca.
The expression of calcitropic genes and proteins were localized within murine placenta during late gestation (the time frame of active calcium transfer) using an analysis of several gene-deletion mouse models by immunohistochemistry and in situ hybridization. Parathyroid hormone-related protein (PTHrP), the PTH/PTHrP receptor, calcium receptor, calbindin-D9k, Ca2+-ATPase and vitamin D receptor were all highly expressed in a localized structure of the murine placenta, the intraplacental yolk sac, as compared to trophoblasts. In the Pthrp-null placenta in which placental calcium transfer is decreased, calbindin-D9k expression was downregulated in the intraplacental yolk sac but not in the trophoblasts. These observations indicated that the intraplacental yolk sac contains calcium transfer and calcium-sensing capability, and that it is a probable route of maternal-fetal calcium exchange in the mouse.
This article has been cited by other articles:
|
|
 |
|
  H. Bond, M. R. Dilworth, B. Baker, E. Cowley, A Requena Jimenez, R. D. H. Boyd, S. M. Husain, B. S. Ward, C. P. Sibley, and J. D. Glazier Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice J. Physiol., April 1, 2008; 586(7): 2015 - 2025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jiang and G. E. Herman Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development Hum. Mol. Genet., November 15, 2006; 15(22): 3293 - 3305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mu and S. L. Adamson Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1421 - H1428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Hewitt, P. J. Mark, A. M. Dharmarajan, and B. J. Waddell Placental Expression of Secreted Frizzled Related Protein-4 in the Rat and the Impact of Glucocorticoid-Induced Fetal and Placental Growth Restriction Biol Reprod, July 1, 2006; 75(1): 75 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Kovacs, M. L. Woodland, N. J. Fudge, and J. K. Friel The vitamin D receptor is not required for fetal mineral homeostasis or for the regulation of placental calcium transfer in mice Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E133 - E144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. McDonald, N. J. Fudge, J. P. Woodrow, J. K. Friel, A. O. Hoff, R. F. Gagel, and C. S. Kovacs Ablation of calcitonin/calcitonin gene-related peptide-{alpha} impairs fetal magnesium but not calcium homeostasis Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E218 - E226. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
