AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (May 16, 2006). doi:10.1152/ajpendo.00366.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
291/4/E860    most recent
00366.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kinman, R. P.
Right arrow Articles by Brunengraber, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kinman, R. P.
Right arrow Articles by Brunengraber, H.
Submitted on August 5, 2005
Accepted on May 8, 2006

Parenteral and Enteral Metabolism of Anaplerotic Triheptanoin in Normal Rats

Renee P. Kinman1, Takhar Kasumov2, Kathryn A. Jobbins2, Katherine R. Thomas2, Jillian Adams2, Lisa N. Brunengraber2, Gerd Kutz3, Wolf-Ulrich Brewer4, Charles R. Roe5, and Henri Brunengraber2*

1 Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States; Nutrition, Case Western Reserve University, Cleveland, Ohio, United States
2 Nutrition, Case Western Reserve University, Cleveland, Ohio, United States
3 Fachhochschule Lippe und Hoxter University of Applied Sciences, Detmold, Germany
4 N/A, SASOL GmbH, Witten, Germany
5 Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas, United States

* To whom correspondence should be addressed. E-mail: hxb8{at}case.edu.

A new chronic treatment for inherited disorders of long-chain fatty acid oxidation involves administering up to one-third of dietary calories as triheptanoin, a medium-odd-chain triglyceride (Roe et al J. Clin. Invest. 110: 259, 2002). Heptanoate and C5-ketone bodies derived from its partial oxidation in liver are precursors of anaplerotic propionyl-CoA in peripheral tissues. It was hypothesized that increasing anaplerosis in peripheral tissues would boost energy production. In the present study, we tested the potential of a triheptanoin emulsion as an intravenous nutrient. Normal rats were infused with triheptanoin intravenously or intraduodenally at up to 40% of caloric requirement. The blood concentration ratio (heptanoate)/(C5-ketone bodies) was high with intravenous, and low with intraduodenal triheptanoin infusion. During intravenous infusion of triheptanoin, lipolysis was stimulated, but appeared compensated by fatty acid re-esterification. During intraduodenal infusion of triheptanoin, lipolysis was not stimulated. Our data support the hypothesis that intravenous triheptanoin could be used to treat decompensated patients with long-chain fatty acid oxidation disorders.




This article has been cited by other articles:


Home page
 NeurologyHome page
C. R. Roe, B-Z Yang, H. Brunengraber, D. S. Roe, M. Wallace, and B. K. Garritson
Carnitine palmitoyltransferase II deficiency: Successful anaplerotic diet therapy
Neurology, July 22, 2008; 71(4): 260 - 264.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.