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Articles in PresS, published online ahead of print December 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00365.2002
Submitted on August 17, 2002
Accepted on November 26, 2002
1 Department of Medicine, University of Rochester School of Medicine, Rochester, NY, USA
2 Department of Medicine, University of Rochester School of Medicine, Rochester, NY, USA; Department of Physiology and Pharmacology, University of Rochester School of Medicine, Rochester, NY, USA
* To whom correspondence should be addressed. E-mail: johngerich{at}compuserve.com.
In order to characterize postprandial glucose disposal more completely, we used the tritiated water technique, a triple isotope approach (intravenous [3-H3] glucose and [14C] bicarbonate and oral 6,6-2H2 glucose) and indirect calorimetry to assess splanchnic and peripheral glucose disposal, direct and indirect glucose storage, oxidative and nonoxidative glycolysis and the glucose entering plasma via gluconeogenesis after ingestion of a meal in 11 normal volunteers. During a six-hour postprandial period, a total of ~98 g glucose were disposed of. This was more than the glucose contained in the meal (~78g) due to persistent endogenous glucose release (~21g): splanchnic tissues initially took up ~23g and an additional ~75g were removed from the systemic circulation. Direct glucose storage accounted for ~32g and glycolysis for ~66g (oxidative ~43g and nonoxidative ~23g). About 11g glucose appeared in plasma as a result of gluconeogenesis. If these carbons were wholly from glucose undergoing glycolysis, only ~12g would be available for indirect pathway glycogen formation. Our results thus indicate that glycolysis is the main initial postprandial fate of glucose, accounting for ~66% of overall disposal; oxidation and storage each account for ~45%. The majority of glycogen is formed via the direct pathway (~73%).
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