| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Human Performance Laboratory, East Carolina University, Greenville, North Carolina, United States
2 Exercise and Sport Science, East Carolina University, Greenville, North Carolina, United States
3 Surgery, East Carolina University, Greenville, North Carolina, United States
* To whom correspondence should be addressed. E-mail: houmardj{at}ecu.edu.
Obesity is associated with a decrement in the ability of skeletal muscle to oxidize lipid. The purpose of this investigation was to determine if clinical interventions (weight loss, exercise training) could reverse the impairment in fatty acid oxidation (FAO) evident in extremely obese individuals. FAO was assessed by incubating skeletal muscle homogenates with 1-14C palmitate and measuring 14CO2 production. Weight loss was studied using both cross-sectional and longitudinal designs. Muscle FAO in extremely obese women who had lost weight (decrease in body mass of ~50 kg) was compared to extremely obese and lean individuals (BMI of 22.8 ± 1.2, 50.7 ± 3.9, and 36.5 ± 3.5 kg/m2 for lean, obese, and obese after weight loss, respectively). There was no difference in muscle FAO between the extremely obese and weight-loss groups and FAO was depressed (P 
0.05) (-45%) compared to the lean subjects. Muscle FAO also did not change in extremely obese women (n=8) before and one-year after a 55 kg weight loss. In contrast, 10 consecutive days of exercise training increased (P 0.05) FAO in the skeletal muscle of lean (+1.7-fold), obese (+1.8-fold) and previously extremely obese subjects after weight loss (+2.6-fold). mRNA content for PDK4, CPT1, and PGC1
corresponded with FAO in that there were no changes with weight loss and an increase with physical activity. These data indicate that a defect in the ability to oxidize lipid in skeletal muscle is evident with obesity which is corrected with exercise training but persists after weight loss.
This article has been cited by other articles:
|
|
 |
|
  T. P. Solomon, J. M Haus, K. R Kelly, M. D Cook, M. Riccardi, M. Rocco, S. R Kashyap, H. Barkoukis, and J. P Kirwan Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans Am. J. Clinical Nutrition, November 1, 2009; 90(5): 1222 - 1229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schenk, M. P. Harber, C. R. Shrivastava, C. F. Burant, and J. F. Horowitz Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity J. Physiol., October 15, 2009; 587(20): 4949 - 4961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kawasaki, F. Hokari, M. Sasaki, A. Sakai, K. Koshinaka, and K. Kawanaka Role of local muscle contractile activity in the exercise-induced increase in NR4A receptor mRNA expression J Appl Physiol, June 1, 2009; 106(6): 1826 - 1831. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R Short Introduction to symposium proceedings: the emerging interplay among muscle mitochondrial function, nutrition, and disease Am. J. Clinical Nutrition, January 1, 2009; 89(1): 453S - 454S. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
