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Am J Physiol Endocrinol Metab (October 30, 2001). doi:10.1152/ajpendo.00352.2001
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Articles in PresS, published online ahead of print October 29, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00352.2001
Submitted on August 3, 2001
Accepted on October 19, 2001

Effect of ibuprofen and acetaminophen on post-exercise muscle protein synthesis

Todd A Trappe1*, Faber White1, Charles P Lambert1, Denise Cesar2, Marc Hellerstein2, and William J Evans1

1 Donald W. Reynolds Department of Geriatrics, Nutrition, Metabolism, and Exercise Laboratory, University of Arkansas for Medical Sciences, Little Rock, AR, USA
2 Department of Nutritional Sciences, University of California, Berkeley, Berkeley, CA, USA

* To whom correspondence should be addressed. E-mail: trappetodda{at}uams.edu.

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness following high intensity eccentric resistance exercise. Twenty four males (25 ±3 y, 180 ±6 cm, 81 ±6 kg, and 17 ±8 % body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1200 mg*d-1), acetaminophen (ACET; 4000 mg*d-1), or a placebo (PLA) following 10-14 sets of 10 eccentric repetitions at 120% of concentric 1 repetition maximum using the knee extensors. Post-exercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 ±19% (p<0.05) in PLA (0.058 ±0.012 %*h-1), and was unchanged (p>0.05) in IBU (35 ±21%; 0.021 ±0.014 %*h-1) and ACET (22 ±23%; 0.010 ±0.019 %*h-1). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle following eccentric resistance exercise. Thus, these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.




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