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Am J Physiol Endocrinol Metab (November 26, 2002). doi:10.1152/ajpendo.00350.2002
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Articles in PresS, published online ahead of print November 26, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00350.2002
Submitted on August 8, 2002
Accepted on November 18, 2002

Chronic intracerebroventricular infusion of MCH causes obesity in mice

Akira Gomori1, Akane Ishihara1*, Masahiko Ito1, Satoshi Mashiko1, Hiroko Matsushita1, Mariko Yumoto1, Makoto Ito1, Takeshi Tanaka1, Shigeru Tokita1, Minoru Moriya1, Hisashi Iwaasa1, and Akio Kanatani1

1 Banyu Pharmaceutical Co., Ltd., Tsukuba Research Institute, Tsukuba, Ibaraki, Japan

* To whom correspondence should be addressed. E-mail: isihraan{at}banyu.co.jp.

Melanin-concentrating hormone (MCH) is a cyclic amino acid neuropeptide localized in the lateral hypothalamus. Although MCH is thought to be an important regulator of feeding behavior, the involvement of this peptide in body weight control has been still unclear. To examine the role of MCH in development of obesity, we assessed the effect of chronic intracerebroventricular (ICV) infusion of MCH in C57BL/6J mice that were fed with regular or moderately high fat (MHF) diets. ICV infusion of MCH (10 µg/day for 14 days) caused a slight but significant increase in body weight in mice maintained on the regular diet. In the MHF diet-fed mice, MCH more clearly increased the body weight accompanied with a sustained hyperphagia and significant increase in fat and liver weights. Plasma glucose, insulin and leptin levels were also increased in the MCH-treated mice fed with the MHF diet. These results suggest that chronic stimulation of the brain MCH system causes obesity in mice, and imply that MCH may have a major role in energy homeostasis.




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