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Am J Physiol Endocrinol Metab (October 26, 2004). doi:10.1152/ajpendo.00340.2004
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Submitted on July 28, 2004
Accepted on October 22, 2004

Isotope Tracer Measures of Meal Fatty Acid Metabolism: Reproducibility and Effects of the Menstrual Cycle

Ana Paola Uranga1, James Levine1, and Michael Jensen1*

1 Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA

* To whom correspondence should be addressed. E-mail: jensen.michael{at}mayo.edu.

Adding isotopic tracers of fatty acids to meals allows investigators to measure the oxidation and adipose tissue uptake of dietary fat. The present studies were conducted to measure the between-study variability of these types of experiments and to assess whether dietary fatty acids are handled differently in the follicular vs. luteal phase of the menstrual cycle. Healthy, normal weight men (n=12) and women (n=12) participated in these studies, which block randomized to control for study order, isotope (3H triolein vs. 14C triolein), and menstrual cycle. Energy expenditure (indirect calorimetry), meal fatty acid oxidation, and meal fatty acid uptake into upper body and lower body subcutaneous fat (biopsies) 24 hours after the experimental meal were measured. Results: A greater portion of meal fatty acids were stored in upper body subcutaneous adipose tissue (24±2% vs. 16±2%, p<0.005) and in lower body fat (12±1% vs. 7±1%, p<0.005) in women than men. Meal fatty acid oxidation (3H2O generation) was greater in men than women (52±3% vs. 45±2%, p=0.04). Leg adipose tissue uptake of meal fatty acids was 15±2% in the follicular phase of the menstrual cycle and 10±1% in the luteal phase (P = NS). The variance and skewness of leg fatty acid uptake was somewhat greater in women than in men (P = NS); the variance in upper body meal fatty acid uptake did not differ between men and women. We conclude that leg uptake of dietary fat is slightly more variable in women than in men, but that there are no major effects of the menstrual cycle on meal fatty acid disposal.




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