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Articles in PresS, published online ahead of print December 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00338.2002
Submitted on July 29, 2002
Accepted on December 6, 2002
1 Physical Education, Universite Catholique de Louvain, Brussels, Belgium
2 Physical Education, Universite Libre de Bruxelles, Brussels, Belgium
3 Department of Physiology, Karolinska Institute, Stockholm, Sweden
4 Department of Nutrition, Universite de Poitiers, Poitiers, France, Metropolitan
5 Department of Nutrition, Massachusetts Institute of Technology, Cambridge, MA, USA
6 Department of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
* To whom correspondence should be addressed. E-mail: m.j.rennie{at}dundee.ac.uk.
Dietary creatine supplementation is associated with increases in muscle mass but the mechanism is unknown. We tested the hypothesis that creatine supplementation enhanced myofibrillar protein synthesis (MPS) and diminished muscle protein breakdown (MPB) in the fed state. Six healthy men (26 ± 7 y, BMI 22 ± 4 kg m-2) were studied twice, 2-4 w apart, before and after ingestion of creatine (21 g.day-1, 5 days). We carried out two sets of measurements within 5.5 h of both MPS (by incorporation of [1-13C]leucine into quadriceps muscle) and MPB (as dilution of [1-13C]leucine or [2H5]phenylalanine across the forearm); for the first 3 h the subjects were post-absorptive but thereafter were fed orally (0.3 g maltodextrin and 0.083 g protein.kg-1 body wt.h-1). Creatine supplementation increased muscle total creatine by ~30%(P<0.01). Feeding had significant effects, doubling MPS (P<0.001) and depressing MPB by ~40% (P<0.026) but creatine had no effect on turnover in the postabsorptive or fed states. Thus any increase in muscle mass accompanying creatine supplementation must be associated with increased physical activity.
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