| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Surgery, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, Texas, USA
* To whom correspondence should be addressed. E-mail: melmoore{at}utmb.edu.
Regular aerobic exercise strongly influences muscle metabolism in elderly and young,
however, the acute effects of aerobic exercise on protein metabolism are not fully understood.
We investigated the effect of a single bout of moderate walking (45 min at ~ 40% of VO2peak) on
post-exercise (POST-EX) muscle metabolism and synthesis of plasma proteins (albumin, ALB
and fibrinogen, FIB) in untrained older (n=6) and younger (n=6) men. We measured muscle
phenylalanine kinetics before (REST) and after aerobic exercise (10, 60 and 180 min) using L-
[ring-2H5]-phenylalanine (Phe) infusion, femoral arteriovenous (AV) blood samples and muscle
biopsies. All data are presented as the difference from REST (
from REST at 10, 60 and 180
min POST-EX). Mixed muscle fractional synthesis rate (FSR) increased significantly at 10 min
POST-EX in both the younger (.0363 %/h) and older men (.0830 %/h), with the younger men
staying elevated through 60 min POST-EX (.0253 %/h). ALB FSR increased at 10 min POST-EX
in the younger men only (2.30 %/d), whereas FIB FSR was elevated in both groups through
180 min POST-EX (younger men = 4.149 %/d; older men = 4.107 %/d). Muscle protein turnover
was also increased, with increases in synthesis and breakdown in younger and older men. Phe
rate of disappearance (Rd: synthesis) was increased in both groups at 10 min POST-EX and
remained elevated through 60 min POST-EX in the older men. A bout of moderate intensity
aerobic exercise induces short-term increases in muscle and plasma protein synthesis in both
younger and older men. Aging per se does not diminish the protein metabolic capacity of the
elderly to respond to acute aerobic exercise.
This article has been cited by other articles:
|
|
 |
|
  S. B. Wilkinson, S. M. Phillips, P. J. Atherton, R. Patel, K. E. Yarasheski, M. A. Tarnopolsky, and M. J. Rennie Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle J. Physiol., August 1, 2008; 586(15): 3701 - 3717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Beelen, R. Koopman, A. P. Gijsen, H. Vandereyt, A. K. Kies, H. Kuipers, W. H. M. Saris, and L. J. C. van Loon Protein coingestion stimulates muscle protein synthesis during resistance-type exercise Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E70 - E77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Anthony, B. J. McDaniel, P. Knoll, P. Bunpo, G. L. Paul, and M. A. McNurlan Feeding Meals Containing Soy or Whey Protein after Exercise Stimulates Protein Synthesis and Translation Initiation in the Skeletal Muscle of Male Rats J. Nutr., February 1, 2007; 137(2): 357 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fujita, B. B. Rasmussen, J. A. Bell, J. G. Cadenas, and E. Volpi Basal muscle intracellular amino acid kinetics in women and men Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E77 - E83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Cuthbertson, J. Babraj, K. Smith, E. Wilkes, M. J. Fedele, K. Esser, and M. Rennie Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E731 - E738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Pikosky, P. C. Gaine, W. F. Martin, K. C. Grabarz, A. A. Ferrando, R. R. Wolfe, and N. R. Rodriguez Aerobic Exercise Training Increases Skeletal Muscle Protein Turnover in Healthy Adults at Rest J. Nutr., February 1, 2006; 136(2): 379 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Bolster, M. A. Pikosky, P. C. Gaine, W. Martin, R. R. Wolfe, K. D. Tipton, D. Maclean, C. M. Maresh, and N. R. Rodriguez Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E678 - E683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F Miller, J. L Olesen, M. Hansen, S. Dossing, R. M Crameri, R. J Welling, H. Langberg, A. Flyvbjerg, M. Kjaer, J. A Babraj, et al. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise J. Physiol., September 15, 2005; 567(3): 1021 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sheffield-Moore, D. Paddon-Jones, A. P. Sanford, J. I. Rosenblatt, A. G. Matlock, M. G. Cree, and R. R. Wolfe Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E922 - E929. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
