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Articles in PresS, published online ahead of print April 9, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00334.2001
Submitted on August 1, 2001
Accepted on March 21, 2002
1 Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA
2 National Center for Alternative Medicine, Bethesda, MD, USA; Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA
3 Kronos Longevity Research Institute, Phoenix, AZ, USA; Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, USA
* To whom correspondence should be addressed. E-mail: metterj{at}grc.nia.nih.gov.
Muscle mass and strength losses during aging may be associated with declining levels of serum testosterone (T) in men. Few studies have shown a direct relationship between T and muscle mass and strength. Subjects were 262 men, aged 24-90 years from the Baltimore Longitudinal Study of Aging who had T and SHBG measurements, from which free T index (FTI) was calculated (T/SHBG), from serum samples collected longitudinally since 1963, total body fat mass and arm and leg fat-free mass (FFM) by dual energy x-ray absorptiometry, and arm and leg strength by dynanomometry. Mixed effects models estimated T and FTI at the time of mass and strength measurements. Age, total body fat, arm and leg FFM, T and FTI were significantly associated with concentric and eccentric strength. FTI, not T, was modestly, but directly, related to arm and leg strength, after accounting for fat, arm and leg FFM, height and age, and indirectly through body mass. FTI is a better predictor of arm and leg strength than T in aging men.
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