AJP - Endo Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (September 3, 2003). doi:10.1152/ajpendo.00332.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
286/1/E20    most recent
00332.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maresh, C. M.
Right arrow Articles by Hamilton, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maresh, C. M.
Right arrow Articles by Hamilton, A. J.
Submitted on July 18, 2003
Accepted on August 27, 2003

The effects of high altitude and water deprivation on AVP release in man

C. M. Maresh1*, W. J. Kraemer1, D. A. Judelson1, J. L. VanHeest1, L. Trad2, J. M. Kulikowich1, K. L. Goetz3, A. Cymerman2, and A. J. Hamilton4

1 Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, USA
2 United States Army Research Institute of Environmental Medicine, Natick, MA, USA
3 Division of Experimental Medicine, St. Luke's Hospital and Foundation for Medical Education and Research, Kansas City, MO, USA
4 United States Army Research Institute of Environmental Medicine, Natick, MA, USA; Department of Surgery, University of Arizona Health Sciences Center, Tucson, AZ, USA

* To whom correspondence should be addressed. E-mail: carl.maresh{at}uconn.edu.

High altitude exposure changes the distribution of body water and electrolytes. Arginine vasopressin (AVP) may influence these alterations. The purpose of this study was to examine the effect of a 24-hour water deprivation trial (WDT) on AVP release after differing altitude exposures. Seven healthy males (age=22±1yrs, height=176±2cm, mass=75.3±1.8kg) completed three WDTs: at sea level (SL), after acute altitude exposure (two days) to 4300m (AA), and after prolonged altitude exposure (20 days) to 4300m (PA). Body mass, standing and supine blood pressures, plasma osmolality (Posm), and plasma AVP (PAVP) were measured at 0, 12, 16, and 24 hours of each WDT. Urine volume was measured at each void throughout testing. Baseline Posm increased from SL to altitude (SL=291.7±0.8mOsm.L-1, AA=299.6±2.2mOsm.L-1, PA=302.3±1.5mOsm.L-1, p<0.05), however, baseline PAVP measurements were similar. Despite similar Posm values, the maximal PAVP response during the WDT (at 16 hours) was greater at altitude than SL (SL=1.7±0.5pg.ml-1, AA=6.4±0.7pg.ml-1, PA=8.7±0.9pg.ml-1, p<0.05). In conclusion, hypoxia appeared to alter AVP regulation by raising the osmotic threshold and increasing AVP responsiveness above that threshold.




This article has been cited by other articles:


Home page
 CirculationHome page
L. J. Rubin
Endothelin-1 and the Pulmonary Vascular Response to Altitude: A New Therapeutic Target?
Circulation, September 26, 2006; 114(13): 1350 - 1351.
[Full Text] [PDF]

Home page
 CirculationHome page
P. A. Modesti, S. Vanni, M. Morabito, A. Modesti, M. Marchetta, T. Gamberi, F. Sofi, G. Savia, G. Mancia, G. F. Gensini, et al.
Role of Endothelin-1 in Exposure to High Altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) Study
Circulation, September 26, 2006; 114(13): 1410 - 1416.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.