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Am J Physiol Endocrinol Metab (April 16, 2002). doi:10.1152/ajpendo.00321.2001
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Articles in PresS, published online ahead of print April 16, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00321.2001
Submitted on July 24, 2001
Accepted on April 1, 2002

Salmon cardiac natriuretic peptide is a volume regulating hormone

Virpi Tervonen1, Heikki Ruskoaho2, Tiina Lecklin3, Mika Ilves1, and Olli Vuolteenaho1*

1 Department of Physiology, University of Oulu, Oulu, Finland; Biocenter Oulu, Univiversity of Oulu, Oulu, Finland
2 Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland; Biocenter Oulu, Univiversity of Oulu, Oulu, Finland
3 Department of Biology, University of Turku, Turku, Finland

* To whom correspondence should be addressed. E-mail: olli.vuolteenaho{at}oulu.fi.

The present study tested the hypothesis that salmon cardiac peptide (sCP), a new member of the family of natriuretic peptides, has an important role in the regulation of the fluid balance and cardiovascular function. Intra-arterial administration of sCP increased urine output in salmon. It had a diuretic effect in rat as well, but the potency was lower. sCP increased the sodium excretion in proportion to the increased urine flow. Blood pressure was not affected by sCP in either species. Acute volume expansion elevated the plasma level of sCP in salmon, and an acute transfer of salmon from fresh to sea water decreased the circulating sCP level. Cardiac immunoreactive sCP or sCP mRNA levels were not affected by transfer to sea water. These results indicate that sCP has an important physiological role in defending salmon against volume overload, but that it does not appear to contribute to the short-term regulation of the blood pressure. sCP provides an excellent model of the general mechanisms of regulation of the A-type natriuretic peptide system.




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Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1360 - H1370.
[Abstract] [Full Text] [PDF]


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