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Articles in PresS, published online ahead of print November 12, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00302.2002
Submitted on July 11, 2002
Accepted on October 6, 2002
1 The Steadward Center for Personal and Physical Achievement, University of Alberta, Edmonton, AB, Canada; Department of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada
2 Department of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada
3 The Steadward Center for Personal and Physical Achievement, University of Alberta, Edmonton, AB, Canada
* To whom correspondence should be addressed. E-mail: justin.jeon{at}ualberta.ca.
We studied plasma leptin levels in six people with high lesion spinal cord injury (SCI) [body mass index (BMI) 25.9 ± 1.5 kg/m2, age 37±3.0 yrs] and six able-bodied (AB) controls (BMI 29.1±1.9 kg/m2, age 35±3.5 yrs) before, 12h, 24h and 36h of fasting. The plasma leptin levels significantly decreased during 36h fasting by 48.8 ± 4.5% (pre: 11.3 ±2.3, post: 6.2±1.5 ng/ml) and 38.6±7.9% (pre: 7.6±5.0, post: 4.2±1.0 ng/ml) in SCI and AB, respectively. Plasma leptin started to decrease at 24h of fasting in the SCI group while plasma leptin started to decrease at 12 h of fasting in the AB group. The current study demonstrated that plasma leptin decreased with fasting in both SCI and AB group, with the leptin decrease being delayed in the SCI group. The delayed leptin response to fasting in the SCI group may be due to increased fat mass (percent body fat, SCI: 33.8±3.0, AB: 24.1±2.9%)and sympathetic nervous system (SNS) dysfunction.
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