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Am J Physiol Endocrinol Metab (October 30, 2001). doi:10.1152/ajpendo.00296.2001
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Articles in PresS, published online ahead of print October 29, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00296.2001
Submitted on July 9, 2001
Accepted on September 26, 2001

Physical Exercise Prevents The Development Of Type 2 Diabetes Mellitus In Psammomys Obesus

Yuval Heled1, Yair Shapiro1, Yoav Shani1, Dani S Moran1, Lea Langzam2, Liora Braiman2, Sanford R Sampson2, and Joseph Meyerovitch3*

1 Heller Institute of Medical Research, Sackler School of Medicine, Sheba Medical Center Tel-Hashomer, Ramat-Gan, Israel
2 Faculty of Life Science, Gonda-Goldschmied Center, Bar-Ilan University, Ramat-Gan, Israel
3 Pediatric Division, Sackler School of Medicine, Sheba Medical Center Tel-Hashomer, Ramat-gan, Israel

* To whom correspondence should be addressed. E-mail: josephm{at}post.tau.ac.il.

We hypothesized that exercise training might prevent diabetes mellitus in Psammomys obesus. Animals were assigned to 3 groups: high-energy diet-CH, high-energy diet and exercising-EH, and low-energy diet-CL. The EH group ran on a treadmill 5 days a week, twice a day. After 4 weeks 93% of the CH group were diabetic compared with only 20% of the EH group. There was no difference in weight gain among the groups. Both EH and CH groups were hyperinsulinemic. Epididymal fat (% of body-weight) was higher in the CH group compared with both the EH and CL groups. PKC{delta} activity and serine phosphorylation were higher in the EH group. No differences were found in tyrosine phosphorylation of IR, IRS-1 and PI3Kinase among the groups. We demonstrate for the first time that exercise training effectively prevents the progression of diabetes mellitus type-2 in Psammomys obesus. PKC{delta} may be involved in the adaptive effects of exercise in skeletal muscles that lead to the prevention of type-2 diabetes mellitus.




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