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Am J Physiol Endocrinol Metab (December 7, 2004). doi:10.1152/ajpendo.00292.2004
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Submitted on July 2, 2004
Accepted on December 4, 2004

Sympathetic nervous system activity in rat thyroid: Potential role in goitrogenesis

James B. Young1*, M. Elizabeth Burgi-Saville1, Ulrich Burgi1, and Lewis Landsberg1

1 Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA; Endocrine and Diabetes Division, University Clinic of Medicine, Inselspital, Bern, Switzerland

* To whom correspondence should be addressed. E-mail: jbyoung{at}northwestern.edu.

The role of sympathetic innervation in regulation of thyroid function is incompletely understood. Studies, therefore, were carried out in rats utilizing techniques of norepinephrine turnover to assess thyroid sympathetic activity in vivo. Thyroidal sympathetic activity was increased 95% by exposure to cold (4°C), 42% by chronic ingestion of an iodine deficient diet and 32% in rats fed a goitrogenic diet (low iodine diet supplemented with propylthiouracil). In addition, fasting for 2 days reduced SNS activity in thyroid by 38%. Thyroid growth and [125I] uptake were also compared in intact and decentralized hemithyroids obtained from animals subjected to unilateral superior cervical ganglion decentralization (USCGD). USCGD led to a reduction in thyroid weight, in [125I] uptake by thyroid tissue, and in TSH-induced stimulation of [125I] uptake in decentralized hemithyroids. These results suggest that sympathetic activity in thyroid contributes to gland enlargement and may modulate tissue responsiveness to TSH.




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