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1 Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
2 Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA; Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas, USA
* To whom correspondence should be addressed. E-mail: djpaddon{at}utmb.edu.
We sought to determine if ingestion of a between meal supplement containing 30 g carbohydrate and 15 g essential amino acids (CAA) altered the metabolic response to a nutritionally mixed meal in healthy, recreationally active male volunteers. A control group (CON: n=6, 38±8 y; 86±10 kg; 179±3 cm) received a liquid, mixed meal (protein: 23.4±1.0 g [essential amino acids: 14.7±0.7 g], carbohydrate: 126.6±4.0 g, fat: 30.3±2.8 g) every 5 hrs (08:30, 13:30, 18:30). The experimental group (SUP: n=7, 36±10 y; 87±12 kg; 180±3 cm) consumed the same meals but in addition were given CAA supplements (11:00, 16:00, 21:00). Net phenylalanine balance (NB) and fractional synthetic rate (FSR) were calculated during a 16 h primed constant infusion of L-[ring-2H5] phenylalanine. Ingestion of a combination of CAA supplements and meals resulted in a greater mixed muscle FSR than ingestion of the meals alone (SUP: 0.099±0.008 %.h-1; CON: 0.076±0.005 %.h-1), (p<0.05). Both groups experienced an improvement in NB following the morning (SUP: -2.2±3.3; CON: -1.5±3.5 nmol.min-1.100 mL leg volume-1) and evening meals (SUP: -9.7±4.3; CON: -6.7±4.1 nmol.min-1.100 mL leg volume-1). NB following CAA ingestion was significantly greater than the meals, with values of 40.2±8.5 nmol.min-1.100 mL leg volume-1. These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal.
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