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Am J Physiol Endocrinol Metab (October 2, 2001). doi:10.1152/ajpendo.00287.2001
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Articles in PresS, published online ahead of print October 2, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00287.2001
Submitted on July 10, 2001
Accepted on September 27, 2001

Evidence for a corticosterone-dependent influence of the suprachiasmatic nucleus on adrenal sensitivity to ACTH in the rat

Dominique Sage1, Daniel Maurel1, and Olivier Bosler1*

1 Faculte de medecine Nord, Inserm, Marseille, France, France, Metropolitan

* To whom correspondence should be addressed. E-mail: bosler.o{at}jean-roche.univ-mrs.fr.

We investigated the effects of ablation of the suprachiasmatic nucleus (SCN) on corticosterone (CORT) responses to synthetic ACTH given either in the morning or evening. After dexamethasone treatment, evening ACTH injections in intact rats produced a significantly larger increase in plasma CORT compared to morning ones. In rats with SCN lesions, the ACTH-induced CORT secretion was independent of time of day, providing direct evidence for a driving influence of the SCN on the diurnal rhythm of adrenal sensitivity to ACTH. In the absence of dexamethasone treatment, the SCN-lesioned rats were selected for morning-like (ML) or evening-like (EL) basal levels of CORT. Responses to ACTH were not different in ML rats compared to sham-lesioned morning controls. In contrast, EL rats compared to sham-lesioned evening controls showed some 60% decrease in increment of CORT levels within the first 15 minutes post-injection. These results indicate that the SCN upregulates ACTH sensitivity of the adrenal cortex during the ascending phase of the daily CORT secretion and point to a critical role of glucocorticoids in determining SCN action.




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