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Am J Physiol Endocrinol Metab (October 15, 2002). doi:10.1152/ajpendo.00282.2002
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Articles in PresS, published online ahead of print October 15, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00282.2002
Submitted on June 26, 2002
Accepted on October 10, 2002

Sexual dimorphism is associated with decreased expression of processed myostatin in males

Christopher D. McMahon1*, Ljiljana Popovic1, Ferenc Jeanplong1, Jenny M. Oldham1, Sonnie P. Kirk1, Claire C. Osepchook1, Karen W. Wong1, Mridula Sharma1, Ravi Kambadur1, and John J Bass1

1 Department of Animal Genomics, AgResearch Ltd., Ruakura Agricultural Centre, Hamilton, New Zealand

* To whom correspondence should be addressed. E-mail: chris.mcmahon{at}agresearch.co.nz.

Myostatin inhibits skeletal muscle development. Therefore, we sought to determine if larger body and muscle mass in male mice was associated with lower mRNA and protein expression of myostatin, compared with females. Ten male and female mice of the C57 strain were killed at 16 to 18 wk of age and their biceps femoris, gastrocnemius, quadriceps femoris muscles were collected. Body and muscle mass were 40% heavier (P<0.001) in males than in females. Northern analysis showed no difference in mRNA between males and females. In contrast, Western analysis showed that processed myostatin (26 kDa) was 40 to 60% lower (P<0.001) in males compared with females. These data show firstly, that decreased processed myostatin is a post-transcriptional and post-translational event and, secondly, that decreased abundance of processed myostatin is associated with increased body mass and skeletal muscle mass in male, compared with female mice.




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