AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (July 30, 2002). doi:10.1152/ajpendo.00271.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/E1046    most recent
00271.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by D'Eon, T. M
Right arrow Articles by Braun, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by D'Eon, T. M
Right arrow Articles by Braun, B.

Articles in PresS, published online ahead of print July 30, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00271.2002
Submitted on June 20, 2002
Accepted on July 24, 2002

Regulation of Exercise Carbohydrate Metabolism by Estrogen and Progesterone in Women

Tara M D'Eon1, Carrie Sharoff1, Stuart R Chipkin2, Daniel Grow3, Brent C Ruby4, and Barry Braun1*

1 Department of Exercise Science, University of Massachusetts, Amherst, MA, USA
2 Division of endocrinology, Diabetes and Metabolism, Baystate Medical Center, Springfield, MA, USA
3 Department of Obstetrics and Gynecology, Baystate Medical Center, Springfield, MA, USA
4 Department of Health and Human Performance, University of Montana, Missoula, MT, USA

* To whom correspondence should be addressed. E-mail: bbraun{at}excsci.umass.edu.

To assess the roles of E2 and P4 in regulating exercise carbohydrate use, we used pharmacological suppression and replacement to create 3 distinct hormonal environments; Baseline (B), with E2 and P4 low; Estrogen only (E), with E2 high and P4 low); and Estrogen/Progesterone (E+P), with E2 and P4 high. Blood glucose uptake (Rd), total carbohydrate oxidation (CHOox) and estimated muscle glycogen utilization (EMGU) were assessed during 60' of submaximal exercise using stable isotope dilution and indirect calorimetry in 8 eumenorrheic women. Compared with B (1.26±.04 g/min) and E+P (1.27±.04 g/min), CHOox was lower with E (1.05±.02 g/min). Glucose Rd tended to be lower with E and E+P relative to B. EMGU was 25% lower with E compared with B and E+P. Plasma free fatty acids were were inversely related to EMGU (r2 = 0.49). The data suggest that estrogen lowers CHOox by reducing EMGU and glucose Rd. Progesterone increases EMGU but not glucose Rd. The opposing actions of E2 and P4 on EMGU may be mediated by their impact on FFA availability or vice versa.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Devries, M. J. Hamadeh, S. M. Phillips, and M. A. Tarnopolsky
Menstrual cycle phase and sex influence muscle glycogen utilization and glucose turnover during moderate-intensity endurance exercise
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R1120 - R1128.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Horton, G. K. Grunwald, J. Lavely, and W. T. Donahoo
Glucose kinetics differ between women and men, during and after exercise
J Appl Physiol, June 1, 2006; 100(6): 1883 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. W Hoyt, P. K. Opstad, A.-H. Haugen, J. P DeLany, A. Cymerman, and K. E Friedl
Negative energy balance in male and female rangers: effects of 7 d of sustained exercise and food deprivation
Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1068 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Horton, E. K. Miller, and K. Bourret
No effect of menstrual cycle phase on glycerol or palmitate kinetics during 90 min of moderate exercise
J Appl Physiol, March 1, 2006; 100(3): 917 - 925.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Braun, L. Gerson, T. Hagobian, D. Grow, and S. R. Chipkin
No effect of short-term testosterone manipulation on exercise substrate metabolism in men
J Appl Physiol, November 1, 2005; 99(5): 1930 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Jacobs, G. A. Casazza, S.-H. Suh, M. A. Horning, and G. A. Brooks
Fatty acid reesterification but not oxidation is increased by oral contraceptive use in women
J Appl Physiol, May 1, 2005; 98(5): 1720 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. P. Uranga, J. Levine, and M. Jensen
Isotope tracer measures of meal fatty acid metabolism: reproducibility and effects of the menstrual cycle
Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E547 - E555.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Venables, J. Achten, and A. E. Jeukendrup
Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study
J Appl Physiol, January 1, 2005; 98(1): 160 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Perreault, J. M. Lavely, B. C. Bergman, and T. J. Horton
Gender differences in insulin action after a single bout of exercise
J Appl Physiol, September 1, 2004; 97(3): 1013 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. W. Rizkalla, L. Taghrid, M. Laromiguiere, D. Huet, J. Boillot, A. Rigoir, F. Elgrably, and G. Slama
Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men: A randomized controlled trial
Diabetes Care, August 1, 2004; 27(8): 1866 - 1872.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. M. Dean, L. Perreault, R. S. Mazzeo, and T. J. Horton
No effect of menstrual cycle phase on lactate threshold
J Appl Physiol, December 1, 2003; 95(6): 2537 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C.J.M. Halkes, H. van Dijk, C. Verseyden, P.P.Th. de Jaegere, H.W.M Plokker, S. Meijssen, D.W. Erkelens, and M. C. Cabezas
Gender Differences in Postprandial Ketone Bodies in Normolipidemic Subjects and in Untreated Patients With Familial Combined Hyperlipidemia
Arterioscler. Thromb. Vasc. Biol., October 1, 2003; 23(10): 1875 - 1880.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.