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Articles in PresS, published online ahead of print August 20, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00255.2002
Submitted on June 10, 2002
Accepted on August 13, 2002
expression in, and release from, contracting human skeletal muscle
1 The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; The Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
2 The Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
3 The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
4 The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; The Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
* To whom correspondence should be addressed. E-mail: sberg{at}rh.dk.
The aim of the present study was to examine whether IL-6 and TNF-
are expressed in, and released from human skeletal muscle during exercise. We hypothesised that the skeletal muscle will release IL-6, but not TNF-, during exercise because of the previous observations that TNF- negatively affects glucose uptake in skeletal muscle. Six healthy, male subjects performed 180 min of two-legged knee-extensor exercise. Muscle samples were obtained from the vastus lateralis of one limb. In addition, blood samples were obtained from a femoral artery and vein. Plasma was analysed for IL-6 and TNF-. We detected both IL-6 and TNF- mRNA in resting muscle samples and while IL-6 increased (P<0.05) ~100 fold throughout exercise, no significant increase in TNF-a mRNA was observed. Arterial plasma TNF- did not increase during exercise. Furthermore, there was no net release of TNF- either before or during exercise. In contrast, IL-6 increased throughout exercise in arterial plasma and a net IL-6 release from the contracting limb was observed after 120 min of exercise (P<0.05).
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