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Am J Physiol Endocrinol Metab (October 22, 2002). doi:10.1152/ajpendo.00253.2002
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Articles in PresS, published online ahead of print October 22, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00253.2002
Submitted on June 10, 2002
Accepted on October 11, 2002

Skeletal muscle IGF-binding protein 3 and 5 expressions are age, muscle, and load dependent

Espen E. Spangenburg1, Tsghe Abraha1, Tom E. Childs1, James S. Pattison1, and Frank W. Booth1*

1 Department of Biomedical Sciences, Physiology, and the Dalton Cardiovascular Institute, University of Missouri, Columbia, MO, USA

* To whom correspondence should be addressed. E-mail: boothf{at}missouri.edu.

The purpose of the current study was to examine IGFBP-3, -4, and -5 mRNA and protein expression levels as a function of muscle type, age, and regrowth from an immobilization-induced atrophy in Fischer 344 x Brown Norway rats. IGFBP-3 mRNA expression in the 4-mo-old animals was significantly higher in the red and white portions of the gastrocnemius muscle compared to the soleus muscle. However, there was no significant differences in IGFBP-3 mRNA expression between any of the muscle groups in the 30-mo-old animals. There were no significant differences in IGFBP-5 mRNA expression in any of the muscle groups, while in the 30-mo-old animals there was significantly less IGFBP-5 mRNA expression in the white gastrocnemius compared to the red gastrocnemius muscles. While IGFBP-3 and -5 proteins were detected in the type I soleus muscle with Western blot analyses, no detection was observed in the type II red and white portions of the gastrocnemius muscle. Aging from adult (18 mo) to old (30 mo) was associated with decreases in IGFBP-3 mRNA and protein and -5 protein only in the soleus muscle. After 10 days of recovery from 10 days of hindlimb immobilization, IGFBP-3 mRNA and protein increased in soleus muscles from young (4-mos), however only IGFBP-3 protein increased in the old (30-mos) rats. While there were no changes in IGFBP-5 mRNA expression during recovery, IGFBP-5 protein in the 10-day recovery soleus muscle did increase in the young, but not in old rats. As the functions of IGFBPs are to modulate IGF-I action on muscle size and phenotype, it is hypothesized that IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber dominated muscles, aging, and regrowth from atrophy.




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