AJP - Endo Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (September 7, 2004). doi:10.1152/ajpendo.00244.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
288/1/E117    most recent
00244.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takahashi, M.
Right arrow Articles by Ezaki, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takahashi, M.
Right arrow Articles by Ezaki, O.
Submitted on June 10, 2004
Accepted on August 25, 2004

Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size

Mayumi Takahashi1, Yasutomi Kamei2, and Osamu Ezaki1*

1 Division of Clinical Nutrition, National Institute of Health and Nutrition, Tokyo, Japan
2 Division of Clinical Nutrition, National Institute of Health and Nutrition, Tokyo, Japan; Japan Science and Technology Agency, PRESTO, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: ezaki{at}nih.go.jp.

Obesity is a common and serious metabolic disorder in the developed world, which is occasionally accompanied by type II diabetes, atherosclerosis, hypertension and hyperlipidemia. We have found that Mest (Mesoderm specific transcript) / Peg1 (Paternally expressed gene 1) gene expression was markedly enhanced in white adipose tissue of mice with diet-induced and genetically caused obesity/diabetes, but not with streptozotocin-induced diabetes which does not cause obesity. Administration of pioglitazone, a drug for type II diabetes and activator of PPAR{gamma}, in db/db mice reduced the enhanced expression of Mest mRNA in adipose tissue, concomitant with an increase in body weight and a decrease in the size of adipose cells. Ectopic expression of Mest in 3T3-L1 cells caused increased gene expression of adipose markers, such as PPAR{gamma}, C/EBP{alpha} and aP2. In transgenic mice overexpressing Mest in adipose tissue, enhanced expression of the adipose genes was observed. Moreover, adipocytes were markedly enlarged in the transgenic mice. Thus, Mest appears to enlarge adipocytes and could be a novel marker of the size of adipocytes.




This article has been cited by other articles:


Home page
 DiabetesHome page
E. Isganaitis, J. Jimenez-Chillaron, M. Woo, A. Chow, J. DeCoste, M. Vokes, M. Liu, S. Kasif, A.-M. Zavacki, R. L. Leshan, et al.
Accelerated Postnatal Growth Increases Lipogenic Gene Expression and Adipocyte Size in Low-Birth Weight Mice
Diabetes, May 1, 2009; 58(5): 1192 - 1200.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Jimenez-Chillaron, E. Isganaitis, M. Charalambous, S. Gesta, T. Pentinat-Pelegrin, R. R. Faucette, J. P. Otis, A. Chow, R. Diaz, A. Ferguson-Smith, et al.
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice
Diabetes, February 1, 2009; 58(2): 460 - 468.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
L. Nikonova, R. A. Koza, T. Mendoza, P.-M. Chao, J. P. Curley, and L. P. Kozak
Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance
FASEB J, November 1, 2008; 22(11): 3925 - 3937.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. J. Oort, T. A. Knotts, M. Grino, N. Naour, J.-P. Bastard, K. Clement, N. Ninkina, V. L. Buchman, P. A. Permana, X. Luo, et al.
{gamma}-Synuclein Is an Adipocyte-Neuron Gene Coordinately Expressed with Leptin and Increased in Human Obesity
J. Nutr., May 1, 2008; 138(5): 841 - 848.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.