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Articles in PresS, published online ahead of print September 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00234.2002
Submitted on May 29, 2002
Accepted on August 26, 2002
1 Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA; Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas, USA
* To whom correspondence should be addressed. E-mail: ktipton{at}utmb.edu.
The purpose of this study was to determine if the acute anabolic muscle response to resistance exercise and essential amino acids (EAA) reflects the response over 24 h. Seven subjects participated in two 24 h studies: 1) resting (REST); 2) rest plus resistance exercise and consumption of EAA (ES). Net balance across the leg (NB) was determined for four amino acids. 13C6-phenylalanine was infused to determine mixed muscle fractional synthetic rate (FSR). Twenty-four-hour FSR was significantly greater for ES than for REST (P=0.003). Exchange of phenylalanine across the leg was -194 ± 74 (SE) mg for ES and -371 ± 88 mg for REST (P=0.07) over 24 h and 229 ± 42 mg (ES) and 28 ± 15 mg (REST; P<0.01) over 3 h corresponding to exercise and EAA consumption for ES. The difference in phenylalanine exchange between REST and ES was not different for measurements over 24 h and 3 h. Increases in NB during ES were primarily due to increases in protein synthesis. Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24 h response.
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