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Articles in PresS, published online ahead of print August 13, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00227.2002
Submitted on May 23, 2002
Accepted on August 7, 2002
1 Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA; Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA
2 Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada
* To whom correspondence should be addressed. E-mail: Charles.Mobbs{at}mssm.edu.
Plasma levels of the adipocyte product adiponectin, a putative insulin sensitizing agent, are reduced in obesity, whereas plasma levels of resistin, an agent that some believe to confer insulin resistance, are thought to increase with obesity. Since adrenalectomy can increase insulin sensitivity, we hypothesized that adrenalectomy would increase expression of adiponectin and decrease expression of resistin. Therefore we measured adiponectin mRNA, adiponectin peptide and resistin mRNA in adrenalectomized ob/ob mice. Adrenalectomy restored adiponectin expression in ob/ob mice to wild-type levels and stimulated adiponectin peptide to above wild-type levels. Surprisingly, expression of adiponectin and resistin were highly positively correlated even after statistical removal of effects of insulin, glucose, and adiposity. In addition, adiponectin and resistin expression were also highly correlated in diet-induced obese mice. The data support a role for adiponectin in mediating some effects of adrenalectomy on insulin sensitivity.
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