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Am J Physiol Endocrinol Metab (July 30, 2002). doi:10.1152/ajpendo.00225.2002
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Articles in PresS, published online ahead of print July 28, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00225.2002
Submitted on May 23, 2002
Accepted on July 25, 2002

Ethnic Differences in in-vitro Glyceride Synthesis in Subcutaneous and Omental Adipose Tissue

Joseph F Bower1, Satyaprasad Vadlamudi2, and Hisham A Barakat2*

1 Microbiology & Immunology, East Carolina University School of Medicine, Greenville, NC, USA
2 Department of Biochemistry, East Carolina University School of Medicine, Greenville, NC, USA

* To whom correspondence should be addressed. E-mail: barakath{at}mail.ecu.edu.

Considerable evidence suggests that there are ethnic differences in lipid metabolism between African American and Caucasian women, which may result in increased synthesis of fat in adipose tissue. The purpose of this study was to measure the in-vitro rates of 14C- glucose incorporation into the glyceride-glycerol backbone of triglycerides (TG) and diglycerides (DG) in abdominal subcutaneous (SAT) and omental adipose tissue (OAT). Morbidly obese (African American n=15; BMI = 45 ± 2.3, Caucasian n=18; BMI = 51 ± 2.3) and pre-obese (African American n=7; BMI = 27 ± 1.0, Caucasian n=7; BMI = 25 ± 1.0) women were examined in this study. There were no significant differences in the rates of synthesis of either TG or DG in SAT of either pre-obese or obese women. On the other hand, both pre-obese and obese African American women had higher rates of synthesis of TG in OAT compared to their Caucasian counterparts. This increase in TG synthesis in OAT was not due to differences in cell size or rates of reesterification. Thus, African American woman have an increased capacity to synthesize TG in OAT compared to Caucasian women, which may contribute to the higher prevalence of obesity in African American women.




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