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Am J Physiol Endocrinol Metab (October 24, 2006). doi:10.1152/ajpendo.00219.2006
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Submitted on May 8, 2006
Accepted on October 18, 2006

Increased resting energy expenditure, fat oxidation and food intake in patients with highly active antiretroviral therapy -associated lipodystrophy

Jussi Sutinen1* and Hannele Yki-Jarvinen2

1 Department of Medicine, Divisions of Diabetes and Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland
2 Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: jussi.sutinen{at}hus.fi.

Highly active antiretroviral therapy (HAART) is associated with metabolic adverse events such as lipodystrophy in HIV-infected patients. The objective of the present study was to evaluate the effects of HAART-associated lipodystrophy on resting energy expenditure and caloric intake. In this cross-sectional study we compared resting energy expenditure (REE) and energy intake in 30 HAART-treated patients with lipodystrophy (HAART+LD+) with 13 HAART-treated patients without lipodystrophy (HAART+LD-). REE was measured using indirect calorimetry and energy intake by a 3-day diary of food intake. REE (5180 ± 160 vs 4260 ± 150 J/min, P<0.01) and also REE expressed per fat free mass (86 ± 1 vs 78 ± 2 J/kg fat free mass · min, P<0.01) were significantly higher in the HAART+LD+ than the HAART+LD- group. Rate of lipid oxidation was significantly higher in the HAART+LD+ compared to the HAART+LD- group. Total energy and fat intakes were significantly increased in the HAART+LD+ compared to the HAART+LD- group. These results imply that HAART-associated lipodystrophy is associated with increased REE and lipid oxidation, and with increased caloric and fat intake.




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