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Am J Physiol Endocrinol Metab (October 15, 2002). doi:10.1152/ajpendo.00209.2002
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Articles in PresS, published online ahead of print October 15, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00209.2002
Submitted on May 13, 2002
Accepted on September 18, 2002

Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle

Alan A. Sneddon1*, Michael Koll2, Margaret C. Wallace3, Jenny Jones4, John P. Miell4, Peter J. Garlick5, and Victor R. Preedy2

1 Development, Growth and Function, Rowett Research Institute, Aberdeen, United Kingdom
2 Department of Nutrition and Dietetics, King's College, London, United Kingdom
3 Department of Agriculture and Forestery, University of Aberdeen, Aberdeen, United Kingdom
4 Department of Medicine, GKT School of Medicine, King's Denmark Hill Campus, London, United Kingdom
5 Department of Surgery, State University of New York at Stony Brook, New York, Stony Brook, USA

* To whom correspondence should be addressed. E-mail: aas{at}rri.sari.ac.uk.

This study determined whether an acute alcohol dose could inhibit the refeeding response in starved muscle. Rats starved for 24h were pretreated with alcohol or saline, prior to refeeding by intragastric or intravenous infusion of enteral diet (ENT), total parenteral nutrition (TPN) or saline. Refeeding by TPN or ENT stimulated increases in the fractional rate of protein synthesis (ks) in skeletal muscle. Alcohol prevented the increase in ks when refeeding occurred intragastrically (TPN or ENT) (p<0.001) but not intravenously (TPN). On refeeding intragastrically, alcohol inhibited the increase in both 4E-BP1 and p70S6K phosphorylation in plantaris but only caused partial inhibition in soleus muscle (ENT only). When refed intravenously, alcohol had no effect on the increased 4E-BP1 or p70S6K phosphorylation in either muscle. Plasma insulin levels were augmented by alcohol. Alcohol related changes in plasma amino acid concentrations were similar irrespective of the route of feeding whereas IGF-I levels showed differential changes. This is the first study to demonstrate that acute alcohol ingestion impedes the starved-to-fed response in skeletal muscle.




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[Abstract] [Full Text] [PDF]


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