| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Research Division, Joslin Diabetes Center and Department Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States
2 Research Division, Joslin Diabetes Center and Department Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States; Medical Research Laboratory and Department of Clinical Pharmacology, University of Aarhus, Aarhus, Denmark
* To whom correspondence should be addressed. E-mail: laurie.goodyear{at}joslin.harvard.edu.
The AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is activated by acute increases in the cellular [AMP]:[ATP] ratio. In skeletal and/or cardiac muscle, AMPK activity is increased by stimuli such as exercise, hypoxia, ischemia, and osmotic stress. There are many lines of evidence that increasing AMPK activity in skeletal muscle results in increased rates of glucose transport. Although similar to the effects of insulin to increase glucose transport in muscle, it is clear that the underlying mechanisms for AMPK- mediated glucose transport involve proximal signals that are distinct from that of insulin. Here, we discuss the evidence for AMPK regulation of glucose transport in skeletal and cardiac muscle, and describe research investigating putative signaling mechanisms mediating this effect. We also discuss evidence that AMPK may play a role in enhancing muscle and whole body insulin sensitivity for glucose transport under conditions such as exercise, as well as the use of the AMPK activator AICAR to reverse insulin resistant conditions. The identification of AMPK as a novel glucose transport mediator in skeletal muscle is providing important insights for the treatment and prevention of type 2 diabetes.
This article has been cited by other articles:
|
|
 |
|
  N. Bashan, J. Kovsan, I. Kachko, H. Ovadia, and A. Rudich Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species Physiol Rev, January 1, 2009; 89(1): 27 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Nieto-Vazquez, S. Fernandez-Veledo, C. de Alvaro, and M. Lorenzo Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle Diabetes, December 1, 2008; 57(12): 3211 - 3221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Lefort, E. St.-Amand, S. Morasse, C. H. Cote, and A. Marette The {alpha}-subunit of AMPK is essential for submaximal contraction-mediated glucose transport in skeletal muscle in vitro Am J Physiol Endocrinol Metab, December 1, 2008; 295(6): E1447 - E1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fujii, R. C. Ho, Y. Manabe, N. Jessen, T. Toyoda, W. L. Holland, S. A. Summers, M. F. Hirshman, and L. J. Goodyear Ablation of AMP-Activated Protein Kinase {alpha}2 Activity Exacerbates Insulin Resistance Induced by High-Fat Feeding of Mice Diabetes, November 1, 2008; 57(11): 2958 - 2966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nedachi, H. Fujita, and M. Kanzaki Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1191 - E1204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Pedersen, S. J. Lessard, V. G. Coffey, E. G. Churchley, A. M. Wootton, T. Ng, M. J. Watt, and J. A. Hawley High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine J Appl Physiol, July 1, 2008; 105(1): 7 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kaddai, T. Gonzalez, M. Bolla, Y. Le Marchand-Brustel, and M. Cormont The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E162 - E169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Zhu, B. Han, J. Tong, C. Ma, J. M. Kimzey, K. R. Underwood, Y. Xiao, B. W. Hess, S. P. Ford, P. W. Nathanielsz, et al. AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep J. Physiol., May 15, 2008; 586(10): 2651 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lorenzo, S. Fernandez-Veledo, R. Vila-Bedmar, L. Garcia-Guerra, C. De Alvaro, and I. Nieto-Vazquez Insulin resistance induced by tumor necrosis factor-{alpha} in myocytes and brown adipocytes J Anim Sci, April 1, 2008; 86(14_suppl): E94 - E104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Yaspelkis III, S. J. Lessard, D. W. Reeder, J. J. Limon, M. Saito, D. A. Rivas, I. Kvasha, and J. A. Hawley Exercise reverses high-fat diet-induced impairments on compartmentalization and activation of components of the insulin-signaling cascade in skeletal muscle Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E941 - E949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Lira, Q. A. Soltow, J. H. D. Long, J. L. Betters, J. E. Sellman, and D. S. Criswell Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1062 - E1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Jeyapalan, R. A. Orellana, A. Suryawan, P. M. J. O'Connor, H. V. Nguyen, J. Escobar, J. W. Frank, and T. A. Davis Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E595 - E603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Kramer and L. J. Goodyear Exercise, MAPK, and NF-{kappa}B signaling in skeletal muscle J Appl Physiol, July 1, 2007; 103(1): 388 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chabrolle, L. Tosca, and J. Dupont Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis Reproduction, April 1, 2007; 133(4): 719 - 731. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
