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1 Department of Endocrinology and Diabetes, University Hospital of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark
2 Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
3 Department of Endocrinology and Metabolism, University Hospital of Aarhus, Aarhus, Denmark
4 Department of Endocrinology and Diabetes, University Hospital of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark; Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark
5 Department of Endocrinology and Diabetes, University Hospital of Aarhus, Aarhus Kommunehospital, Aarhus, Denmark; Institute of Clinical Pharmacology, University of Aarhus, Aarhus, Denmark
* To whom correspondence should be addressed. E-mail: cbd{at}dadlnet.dk.
GH and cortisol are important act to ensure energy supplies during fasting and stress. In vitro experiments have raised the question whether GH and cortisol mutually potentiate lipolysis. In the current study combined in vivo effects of GH and cortisol on adipose and muscle tissue were explored. Seven lean males were examined four times over 510 min. Microdialysis catheters were inserted in the m. vastus lateralis and in the sc. adipose tissue of the thigh and abdomen. A pancreatic-pituitary clamp was maintained with somatostatin infusion and replacement of GH, insulin and glucagon at baseline levels. At t=150 min administration of either I. NaCl, II. hydrocortisone infusion 2µg/kg/min, III. GH 200µg bolus and IV. combined administration of II. and III. Systemic FFA turnover was estimated by [9,10-3H]palmitate appearance. Circulating levels of glucose, insulin and glucagon were comparable in I-IV. GH levels were similar in I. and II. 0.50±0.08 µg/l (mean±sem). Peak levels during III. and IV. were ~9 µg/l. Cortisol levels rose to ~900 nmol/l in II. and IV. Systemic (ie. palmitate fluxes, s-FFA, s-glycerol) and regional (interstitial adipose tissue and skeletal muscle) markers of lipolysis increased in response to both II. and III. In IV they were higher and equal to the isolated additive effects of the two hormones. In conclusion, we find that GH and cortisol stimulate systemic and regional lipolysis isolated and in an additive manner when co-administered. Based on previous studies, we speculate that the mode of action is mediated though different pathways
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