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1 Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, United States
* To whom correspondence should be addressed. E-mail: jensen{at}mayo.edu.
The mechanism(s) by which sex specific differences in regional body fat distribution develop are not known. We assessed the effects of a high fat meal on fatty acid oxidation and uptake into regional fat depots using isotopic tracers and adipose biopsies. Thirty men (BMI 23.6±0.3 kg/m2) and 29 women (BMI 22.4±|0.3 kg/m2) received a meal containing [3H] triolein. Twelve of the men and 13 of the women received an additional 80 g of triolein in the meal (HF=high fat) and the remainder received a normal fat (NF) meal. Adipose tissue lipoprotein lipase (LPL) activity was measured in the fed and fasted state. After 24 hours, meal fatty acid uptake into subcutaneous adipose tissue was assessed. The efficiency of meal fat uptake into upper body subcutaneous fat was similar in both sexes, but women had a greater leg fat uptake, especially in response to a HF meal (P<0.0001). A correlation between fed state LPL activity and meal fat uptake was found in both upper and lower body fat (P<0.0001, r=0.69). These studies show that in times of net fat storage, women preferentially increase uptake in leg adipose tissue, and this is likely mediated by fed state LPL activity.
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