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1 Universite catholique de Louvain, Brussels, Belgium
2 Universite Libre de Bruxelles, Brussels, Belgium
3 University of Dundee, Dundee, Scotland, United Kingdom
4 Universite de Poitiers, Poitiers, France
* To whom correspondence should be addressed. E-mail: m.j.rennie{at}dundee.ac.uk.
Muscle hypertrophy during resistance training is reportedly increased by creatine supplementation. Having previously failed to find an anabolic effect on muscle protein turnover at rest, either fed or fasted, we have now examined the possibility of a stimulatory effect of creatine in conjunction with acute resistance exercise. Seven healthy men (BMI, 23±2 kg.m-2, 21±1 y, means ± SEM) performed 20 x 10 repetitions of leg extension-flexion at 75% 1-RM in one leg, on two occasions, 4 wk apart, before and after ingesting 21 g.d-1 of creatine for 5 d. The subjects ate ~21g maltodextrin + 6g protein per h for 3 h post-exercise. We measured incorporation of [1-13C]leucine into quadriceps muscle proteins in the rested and exercised legs. Leg protein breakdown (as dilution of [2H5]-phenylalanine) was also assessed in the exercised and rested leg post-exercise. Creatine supplementation increased muscle total creatine by ~21% (P<0.01). Exercise increased the synthetic rates of myofibrillar and sarcoplasmic proteins by 2- 3 fold (P<0.05), and leg phenylalanine balance became more positive, but creatine was without any anabolic effect.
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