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1 Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA
2 Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA; Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA
3 Metabolism Unit, Shriner's Burns Institute and Departments of Anesthesiology and Surgery, University of Texas Medical Branch, Galveston, TX, USA
* To whom correspondence should be addressed. E-mail: thyfaultj{at}mail.ecu.edu.
Skeletal muscle from extremely obese individuals exhibits decreased lipid oxidation compared to muscle from lean controls. It is unknown if this effect is observed in-vivo or if the phenotype is preserved following massive weight loss. The objective of this study was to compare (free fatty acid) FFA oxidation during rest and exercise in female subjects who were either lean (n=7; BMI=22.6 ± 2.2 kg/m2), extremely obese (n=10; BMI=40.8 ± 5.4 kg/m2), or post-gastric bypass patients who had lost greater than 45 kg (weight reduced) (n=6; BMI=33.7 ± 9.9 kg/m2) using tracer (13C palmitate and 14C acetate) methodology and indirect calorimetry. The lean group oxidized significantly more plasma FFA, as measured by % fatty acid uptake oxidized, than the extremely obese or weight reduced group during rest (66.6 ± 14.9 vs. 41.5 ± 16.4 vs. 39.9 ± 15.3%) and exercise (86.3 ± 11.9 vs. 56.3 ± 22.1 vs. 57.3 ± 20.3%). BMI significantly correlated with % of uptake oxidized both during rest (r = -0.455) and exercise (r = -0.459). In conclusion, extremely obese women and weight reduced women both possess inherent defects in plasma FFA oxidation, which may play a role in massive weight gain and associated comorbidities.
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