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Am J Physiol Endocrinol Metab (January 8, 2002). doi:10.1152/ajpendo.00175.2001
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Articles in PresS, published online ahead of print January 8, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00175.2001
Submitted on April 19, 2001
Accepted on December 20, 2001

Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions

Michelle Z Tucker1 and Lorraine P Turcotte1*

1 Department of Kinesiology, University of Southern California, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: turcotte{at}mizar.usc.edu.

The purpose of the present study was to examine the utilization of fatty acids (FA) and muscle substrates by skeletal muscle in young, middle-aged, and old adult rats under conditions of euglycemia with low insulin levels. Male Fischer 344/Brown Norway rats aged 5, 15, or 24 months underwent hindlimb perfusion with a medium of 8 mM glucose, 1 mM palmitate, 25 µU/ml insulin, [1-14C] palmitate, and [3-3H] glucose. Glucose and palmitate uptake were similar among age groups. The percent and total palmitate oxidized (nmol/min/g) was 30-36% and 41-49% lower (p < 0.05) in 15-mo- and 24-mo-old than in 5-mo-old animals. When compared to 5-mo- and 15-mo-old animals, pre- and post-perfusion muscle triglyceride (TG) levels were significantly (p<0.05) elevated 91-305% in red and 118-219% in white muscles of 24-mo-old animals. FABPPM content was 40-64 % higher (p < 0.05) in 24-mo- than in 5-mo- or 15-mo-old animals. In red muscle, hormone-sensitive lipase (HSL) content was 28% lower (p < 0.05) in 24-mo- than 5-mo-old animals. These results indicate that under euglycemic conditions in the presence of low insulin levels, the reduction in FA disposal to oxidation and the decrease in HSL content may contribute to the accumulation of TG in muscle of old animals.




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