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Articles in PresS, published online ahead of print December 17, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00167.2002
Submitted on April 19, 2002
Accepted on December 11, 2002
1 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA; Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, Ohio, USA; Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio, USA
2 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA; Robert Schwartz M.D. Center for Metabolism and Nutrition, MetroHealth Medical Center, Cleveland, Ohio, USA
3 Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio, USA
* To whom correspondence should be addressed. E-mail: sck{at}po.cwru.edu.
Serine plays an important role in intermediary metabolism as a source of one carbon pool for nucleotide biosynthesis, as a precursor for glycine and glucose, and as a contributor to cysteine biosynthesis. A unique serine glycine cycling between the liver and the placenta has been demonstrated in the sheep fetus. We hypothesized that, because of serine's role in growth and development, significant changes in serine metabolism will occur in pregnancy with advancing gestation. The rate of appearance (Ra) of serine and its metabolism was quantified in healthy women longitudinally through pregnancy using [2- 15N13C]serine tracer. The contribution of serine N to urea and the rate of oxidation of serine was measured using precursor-product relation. Plasma serine concentrations and serine Ra were lower in pregnant (P) women, both in early and in late gestation, as compared with non pregnant (NP) women [(Plasma serine: NP 113 ± 24.5, P early 71.9 ± 6.2; P late 68.5 ± 9.6 µmol.L-1), (Serine Ra: NP 152.9 ± 42.8 (7), P early 123.7 ± 21.5 (12), P late 102.8 ± 18.2 (8) µmol.kg-1.h-1)]. Serine contributed ~6% to urea N and 15-20% to plasma glycine pool and oxidation of serine represented ~8% of Ra. There was no significant difference between pregnant and non pregnant subjects. Glucose infusion, 3 mg.kg-1.h-1 in pregnant subjects, resulted in a decrease in serine Ra and an increase in oxidation. The decrease in serine turnover in pregnancy may represent a decrease in alpha amino nitrogen turnover related to decreased rate of branched chain amino acid transamination and caused by pregnancy related hormones aimed at nitrogen conservation and accretion.
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