| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print May 21, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00167.2001
Submitted on April 11, 2001
Accepted on January 8, 2002
* To whom correspondence should be addressed. E-mail: t.ploug{at}mfi.ku.dk.
AMP-activated protein kinase (AMPK) may mediate the stimulatory effect of contraction and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) on glucose transport in skeletal muscle. In muscles with different fiber type composition from fasted rats AICAR increased 2-deoxyglucose transport and total AMPK activity ~2-fold in epitrochlearis (EPI), less in flexor digitorum brevis (FDB) and not at all in soleus muscles. Contraction increased both transport and AMPK activity more than AICAR. In EPI muscles the effects of AICAR and contractions on glucose transport were partially additive, despite a lower AMPK activity with AICAR compared with contraction alone. In EPI from fed rats glucose transport responses were smaller than seen in fasted rats, and AICAR did not increase transport despite an increase in AMPK activity. AICAR and contraction activated both 
1- and 2-isoforms of AMPK. Expression of both isoforms varied with fiber types, and 2 was highly expressed in nuclei. In conclusion, AICAR-stimulated glucose transport varies with muscle fiber type and nutritional state. AMPK is unlikely to be the sole mediator of contraction-stimulated glucose transport.
This article has been cited by other articles:
|
|
 |
|
  S. J. Maarbjerg, S. B. Jorgensen, A. J. Rose, J. Jeppesen, T. E. Jensen, J. T. Treebak, J. B. Birk, P. Schjerling, J. F. P. Wojtaszewski, and E. A. Richter Genetic impairment of AMPK{alpha}2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice Am J Physiol Endocrinol Metab, October 1, 2009; 297(4): E924 - E934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Lee-Young, B. J. Canny, D. E. Myers, and G. K. McConell AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training J Appl Physiol, July 1, 2009; 107(1): 283 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. McConell, A. Manimmanakorn, R. S. Lee-Young, B. E. Kemp, K. C. Linden, and G. D. Wadley Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment J Appl Physiol, November 1, 2008; 105(5): 1422 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Vieira, E. C. Nilsson, A. Nerstedt, M. Ormestad, Y. C. Long, P. M. Garcia-Roves, J. R. Zierath, and M. Mahlapuu Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1032 - E1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Long and J. R. Zierath Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E545 - E552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Omar, H. Fraser, and A. S. Clanachan Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1266 - H1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Thomson, J. D. Brown, N. Fillmore, B. M. Condon, H-J. Kim, J. R. Barrow, and W. W. Winder LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1572 - E1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. T. Putman, K. J. B. Martins, M. E. Gallo, G. D. Lopaschuk, J. A. Pearcey, I. M. MacLean, R. J. Saranchuk, and D. Pette {alpha}-Catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1325 - R1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Jensen, A. J. Rose, Y. Hellsten, J. F. P. Wojtaszewski, and E. A. Richter Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E286 - E292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Jensen, A. J. Rose, S. B. Jorgensen, N. Brandt, P. Schjerling, J. F. P. Wojtaszewski, and E. A. Richter Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1308 - E1317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Miyamoto, T. Toyoda, T. Hayashi, S. Yonemitsu, M. Nakano, S. Tanaka, K. Ebihara, H. Masuzaki, K. Hosoda, Y. Ogawa, et al. Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle J Appl Physiol, March 1, 2007; 102(3): 1007 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Jorgensen, J. T. Treebak, B. Viollet, P. Schjerling, S. Vaulont, J. F. P. Wojtaszewski, and E. A. Richter Role of AMPK{alpha}2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E331 - E339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fujii, N. Jessen, and L. J. Goodyear AMP-activated protein kinase and the regulation of glucose transport Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E867 - E877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Ryder, Y. C. Long, E. Nilsson, M. Mahlapuu, and J. R. Zierath Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle J. Physiol., September 1, 2005; 567(2): 379 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Smith, C. R. Bruce, and D. J. Dyck AMP kinase activation with AICAR further increases fatty acid oxidation and blunts triacylglycerol hydrolysis in contracting rat soleus muscle J. Physiol., June 1, 2005; 565(2): 547 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Smith, C. R. Bruce, and D. J. Dyck AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle J. Physiol., June 1, 2005; 565(2): 537 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Wright, P. C. Geiger, J. O. Holloszy, and D.-H. Han Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1062 - E1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dobrzyn, P. Dobrzyn, S.-H. Lee, M. Miyazaki, P. Cohen, E. Asilmaz, D. G. Hardie, J. M. Friedman, and J. M. Ntambi Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing {beta}-oxidation in skeletal muscle Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E599 - E607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Thomson and S. E. Gordon Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation J Appl Physiol, February 1, 2005; 98(2): 557 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Iglesias, S. M. Furler, G. J. Cooney, E. W. Kraegen, and J.-M. Ye AMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin-Resistant Rats In Vivo Diabetes, July 1, 2004; 53(7): 1649 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shearer, P. T. Fueger, B. Vorndick, D. P. Bracy, J. N. Rottman, J. A. Clanton, and D. H. Wasserman AMP Kinase-Induced Skeletal Muscle Glucose But Not Long-Chain Fatty Acid Uptake Is Dependent on Nitric Oxide Diabetes, June 1, 2004; 53(6): 1429 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Frosig, S. B. Jorgensen, D. G. Hardie, E. A. Richter, and J. F. P. Wojtaszewski 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E411 - E417. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Yu, N. Fujii, M. F. Hirshman, J. M. Pomerleau, and L. J. Goodyear Cloning and characterization of mouse 5'-AMP-activated protein kinase {gamma}3 subunit Am J Physiol Cell Physiol, February 1, 2004; 286(2): C283 - C292. [Abstract] [Full Text]
|
|
|
|
|
|
S. Terada and I. Tabata Effects of acute bouts of running and swimming exercise on PGC-1{alpha} protein expression in rat epitrochlearis and soleus muscle Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E208 - E216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Irrcher, P. J. Adhihetty, T. Sheehan, A.-M. Joseph, and D. A. Hood PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1669 - C1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Nielsen, K. J. W. Mustard, D. A. Graham, H. Yu, C. S. MacDonald, H. Pilegaard, L. J. Goodyear, D. G. Hardie, E. A. Richter, and J. F. P. Wojtaszewski 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle J Appl Physiol, February 1, 2003; 94(2): 631 - 641. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
