| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
2 Department of Medicine, University of Adelaide, Adelaide, Australia
3 Gastoenterology, University Hospital Utrecht, Utrecht, Netherlands
4 Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia
* To whom correspondence should be addressed. E-mail: christine.feinle{at}adelaide.edu.au.
Gastric emptying is a major determinant of glycemia, gastrointestinal hormone release and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, GLP-1, GIP and CCK, antropyloroduodenal motility and energy intake in healthy subjects. Blood glucose, plasma hormone and antropyloroduodenal motor responses to 120 min intraduodenal infusions of glucose at (i) 1 ("G1"), (ii) 2 ("G2"), and (iii) 4 ("G4") kcal/min, or (iv) saline ("control") were measured in 10 healthy males in double-blind, randomized fashion. Immediately after each infusion energy intake at a buffet meal was quantified. Blood glucose rose in response to all glucose infusions (P < 0.05 vs. control), with the effect of G4 and G2 being greater than that of G1 (P < 0.05), but with no difference between G2 and G4. The rises in insulin, GLP-1, GIP and CCK were related to the glucose load (r > 0.82, P < 0.05). All glucose infusions suppressed antral (P < 0.05), but only G4 decreased duodenal, pressure waves (P < 0.01), resulted in a sustained stimulation of basal pyloric pressure (P < 0.01) and decreased energy intake (P < 0.05). In conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, GLP-1, GIP and CCK, antropyloroduodenal motility and energy intake in healthy subjects. These observations have implications for strategies to minimize postprandial glycemic excursions in type-2 diabetes.
This article has been cited by other articles:
|
|
 |
|
  I. M. Brennan, K. L. Feltrin, N. S. Nair, T. Hausken, T. J. Little, D. Gentilcore, J. M. Wishart, K. L. Jones, M. Horowitz, and C. Feinle-Bisset Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women Am J Physiol Gastrointest Liver Physiol, September 1, 2009; 297(3): G602 - G610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Little, N. Gupta, R. M. Case, D. G. Thompson, and J. T. McLaughlin Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R632 - R639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V Seimon, T. Wooster, B. Otto, M. Golding, L. Day, T. J Little, M. Horowitz, P. M Clifton, and C. Feinle-Bisset The droplet size of intraduodenal fat emulsions influences antropyloroduodenal motility, hormone release, and appetite in healthy males Am. J. Clinical Nutrition, June 1, 2009; 89(6): 1729 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ma, M. Bellon, J. M. Wishart, R. Young, L. A. Blackshaw, K. L. Jones, M. Horowitz, and C. K. Rayner Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects Am J Physiol Gastrointest Liver Physiol, April 1, 2009; 296(4): G735 - G739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Seimon, K. L. Feltrin, J. H. Meyer, I. M. Brennan, J. M. Wishart, M. Horowitz, and C. Feinle-Bisset Effects of varying combinations of intraduodenal lipid and carbohydrate on antropyloroduodenal motility, hormone release, and appetite in healthy males Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R912 - R920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Cukier, A. N. Pilichiewicz, R. Chaikomin, I. M. Brennan, J. M. Wishart, C. K. Rayner, K. L. Jones, M. Horowitz, and C. Feinle-Bisset Effect of small intestinal glucose load on plasma ghrelin in healthy men Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R459 - R462. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
