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1 Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, aurora, Colorado, United States
2 Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, University of Miami, miami, Florida, United States
3 Medicine, Denver Health Medical Center, United States; Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, aurora, Colorado, United States
* To whom correspondence should be addressed. E-mail: Matthew.Jackman{at}uchsc.edu.
The trafficking of dietary fat was assessed in obesity prone (OP) and obesity resistant (OR) male and female rats. Test meals containing 1-14C palmitate were delivered through gastric feeding tubes while rats consumed a high carbohydrate diet (HCD), or after 5 days of a high fat diet (HFD). Over the subsequent 24 hours, the appearance of 14C was followed in the GI tract, skeletal muscles (SM), liver, adipose tissues (AT), and expired CO2. There was no difference in the production of 14CO2 between OP and OR rats consuming a HCD. However, after 5 days on a HFD, OR rats produced significantly more 14CO2 following the test meal than OP rats (p<0.001 females, p=0.03 males). The differential oxidation of dietary fat between OP and OR rats on a HFD was not due to differences in absorption, but rather was associated with preferential disposition of tracer to AT in OP rats. Measures of lipoprotein lipase in part explained increased tracer uptake by AT in OP rats, but were not consistent with increased SM tracer uptake in OR rats. Surprisingly, female rats oxidized more tracer than male rats irrespective of phenotype or diet. These results are consistent with the notion that differences in the partitioning of dietary fat between storage in AT and oxidation in SM and L that develop shortly after the introduction of a HFD may in part underlie the differential tendency for OR and OP rats to gain weight on this diet.
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