AJP - Endo AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab (November 5, 2002). doi:10.1152/ajpendo.00156.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/3/E499    most recent
00156.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carlsson, P.-O.
Right arrow Articles by Palm, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carlsson, P.-O.
Right arrow Articles by Palm, F.

Articles in PresS, published online ahead of print November 5, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00156.2002
Submitted on April 12, 2002
Accepted on October 31, 2002

pH IS DECREASED IN TRANSPLANTED RAT PANCREATIC ISLETS

Per-Ola Carlsson1*, Astrid Nordin1, and Fredrik Palm2

1 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
2 Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden; Department of Diagnostic Radiology, Uppsala University, Uppsala, Sweden

* To whom correspondence should be addressed. E-mail: Per-Ola.Carlsson{at}medcellbiol.uu.se.

Recent studies of transplanted pancreatic islets have indicated incomplete revascularization. We investigated the pH, in relation to pO2, in endogenous islets and islets syngeneically transplanted to the renal subcapsular site of non-diabetic and streptozotocin-diabetic recipients. Tissue pH and oxygen tension were measured using microelectrodes. In the endogenous islets, tissue pH was similar to that in arterial blood. In the transplanted islets, tissue pH was 0.11-0.15 pH-units lower. No differences in islet graft pH were seen between non-diabetic and diabetic animals, or if the islet grafts were investigated 1 day or 1 month posttransplantation. The oxygen tension in the endogenous islets was ~35 mmHg. Transplanted islets had a markedly lower tissue oxygen tension both 1 day and 1 month after transplantation. A negative correlation between the tissue oxygen tension and the hydrogen ion concentration was seen in the 1-month-old islet transplants in diabetic animals. In conclusion, decreased oxygen tension in transplanted islets is associated with a decreased tissue pH, suggesting a shift towards more anaerobic glucose metabolism after transplantation.




This article has been cited by other articles:


Home page
 DiabetesHome page
J. Olerud, M. Johansson, J. Lawler, N. Welsh, and P.-O. Carlsson
Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets
Diabetes, July 1, 2008; 57(7): 1870 - 1877.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Lau, G. Mattsson, C. Carlsson, D. Nyqvist, M. Kohler, P.-O. Berggren, L. Jansson, and P.-O. Carlsson
Implantation Site-Dependent Dysfunction of Transplanted Pancreatic Islets
Diabetes, June 1, 2007; 56(6): 1544 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. Mattsson, L. Jansson, A. Nordin, A. Andersson, and P.-O. Carlsson
Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver
Diabetes, April 1, 2004; 53(4): 948 - 954.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.