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1 UMR INRA-INAPG of Nutrition Physiology and Feeding Control, National Institute for Agricultural Research, Paris, France
2 Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA
3 Department of Animal Sciences, University of Illinois, Urbana, IL, USA
* To whom correspondence should be addressed. E-mail: bos{at}inapg.inra.fr.
Previous steady-state, continuous feeding studies have shown that the gut mucosa removes substantial amounts of both dietary and systemic amino acids. However, enteral nutrition is often given under nonsteady-state conditions, as a bolus meal, and this has been shown to influence systemic metabolism. Therefore, our aim was to quantify the relative metabolism of dietary and systemic lysine by the portal-drained viscera (PDV) under nonsteady-state conditions after a single bolus meal. Five 28-d-old piglets implanted with arterial, venous and portal catheters and with an ultrasonic portal flow probe were given an oral bolus feeding of a milk formula containing a trace quantity of intrinsically labeled 15N-soy protein and a continuous i.v. infusion of U-13C-lysine for 8h. Total lysine use by the PDV was maximal 1h after the meal (891 µmol/kg/h) and was predominantly of dietary origin (89%), paralleling the enteral delivery of dietary lysine. Intestinal lysine use returned to a low level after 4h postprandially, and was derived exclusively from the arterial supply until 8h. Cumulative systemic appearance of dietary lysine reached 44% and 80% of the ingested amount 4 and 8h after the meal, respectively, while the PDV first-pass use of dietary lysine was 55% and 32% of the intake for these two periods, respectively. We conclude that the first-pass utilization rate of dietary lysine by the PDV is directly increased by the enteral lysine availability and is higher, with bolus compared to continuous oral feeding.
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