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1 Geriatrics, Catholic University of the Sacred Heart, Rome, Italy
2 Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, ROME, Italy
3 Geriatrics, University of Ferrara, Ferrara, Italy
* To whom correspondence should be addressed. E-mail: graziano_onder{at}rm.unicatt.it.
The aim of the present study was to evaluate the mediating role played by obesity on the relationship of free IGF-1 and IGFBP-3 with muscle strength and physical performance.
Muscle strength was measured by hand grip strength. Physical performance was assessed using the walking speed and the Short Physical Performance Battery (SPPB) score. Based on its median value, free IGF-1 was categorized in two groups: low IGF-1 (IGF-1< 0.65 ng/ml; n=174) and high IGF-1 (IGF-1
0.65 ng/ml; n=175). Similarly, IGFBP-3 was categorized in two groups: low IGFBP-3 (IGFBP-3< 4319.9 ng/ml; n=174) and high IGFBP-3 (IGFBP-3 4319.9 ng/ml; n=175). BMI was categorized as follows: < 25 kg/m2 (n=160); 25-29.9 kg/m2 (n=133); 30 kg/m2 (n=56).
Among 349 participants no significant association of IGF-1 and IGFBP-3 with study outcomes was observed. After the study sample was stratified by BMI groups, compared with participants with low IGF-1 level, those with high IGF-1 level had a significant better grip strength (mean±SE: 35.2±1.6 kg vs. 29.2±2.0 kg, p=0.03), walking speed (0.55±0.04 m/sec vs. 0.40±0.04 m/sec, p=0.01) and SPPB score (1.9±0.1 vs. 1.5±0.1 m/sec, p=0.01) only in the group with BMI 30 kg/m2, but not in other BMI groups. A statistically significant interaction between BMI and IGF-1 level was observed on all study outcomes. By contrast, no association was observed between IGFBP-3 and study outcomes, independently of BMI. In conclusion, high IGF-1 level is associated with better physical function in older persons with obesity, but not in those with normal or low BMI.
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