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Articles in PresS, published online ahead of print June 18, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00131.2002
Submitted on March 25, 2002
Accepted on June 14, 2002
1 Anatomy and Histology, University of Pennsylvania, Philadelphia, PA, USA
2 Pharmacaology, Albany College of Pharmacy, Albany, NY, USA
3 Medical Gentics, Thomas Jefferson University, Philadelphia, PA, USA
4 Stratton VA Medical Center, Albany, NY, USA
* To whom correspondence should be addressed. E-mail: chaqour{at}biochem.dental.upenn.edu.
Cysteine-rich protein (Cyr61) and connective tissue growth factor (CTGF) are key immediate early growth factors with functions in cell proliferation, differentiation and extracellular matrix synthesis. Studies were performed to assess the gene expression profile of Cyr61 and CTGF in rat urinary bladder during growth in response to partial outlet obstruction. The mRNA levels of Cyr61 as determined by ribonuclease protection assay, increased sharply after 1 day and remained elevated throughout the time period of the obstruction. This correlates well with increased bladder weight. The CTGF mRNA levels seemed to peak within the second week the urethral obstruction and correlates well with increased type I collagen mRNA. The expression pattern of either Cyr61 or CTGF proteins corroborated those of their respective mRNAs. Immunohistochemical analyses showed that immunoreactivity of Cyr61 was confined to detrusor smooth muscle and that of CTGF was detected within both detrusor muscle and lamina propria layers. These data strongly indicate the involvement of Cyr61 and CTGF in bladder wall remodeling as a result of the outlet obstruction.
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