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Articles in PresS, published online ahead of print July 28, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00108.2002
Submitted on March 8, 2002
Accepted on July 18, 2002
1 School of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia
2 Human Nutrition Unit, Dept. of Biochemistry, The University of Sydney, Sydney, NSW, Australia
3 Rayscan Imaging, Liverpool, NSW, Australia
* To whom correspondence should be addressed. E-mail: stevestannard{at}ozemail.com.au.
The purpose of this study was to determine changes in intramyocellular lipid (IMCL) content in the vastus lateralis of non-diabetic, physically-fit males over 72-hours fasting. Six men, mean age 35 years (range 23-55 years), BMI 23.7 kg.m-2 (21.2-27.4 kg.m-2) undertook a water-only fast for 84 hours. Vastus lateralis IMCL content was determined using proton magnetic-resonance spectroscopy (1H MRS) after 12- and 84-hours fasting. Venous blood was sampled at twelve-hour intervals throughout the fast. IMCL-(CH2)n/water and IMCL-(CH2)n/total creatine ratios increased from 0.00623 ± 0.00065 to 0.0142 ± 0.0015 (mean ± S.E., p = 0.002) and 6.82 ± 0.87 to 14.96 ± 1.73 (p = 0.001) respectively. Plasma FFA, serum triglyceride and whole-blood 3-hydroxybutyrate concentrations increased (p < 0.001, 0.05, 0.03 respectively), whilst plasma glucose and serum insulin concentrations decreased (both p < 0.001) during fasting. In conclusion, 72-hours water-only fasting produces a large increase in plasma FFA concentration, a drop in serum insulin concentration and accumulation of IMCL in the vastus lateralis muscle of non-diabetic, physically-fit men.
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