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1 Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
2 Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
3 Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA; Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
* To whom correspondence should be addressed. E-mail: lidia.szczepaniak{at}utsouthwestern.edu.
Background: The primary aim of this investigation was to determine the reliability and sensitivity of 1H-magnetic resonance spectroscopy (1H-MRS) as a method for quantifying myocardial triglyceride (TG) content in humans over time and in response to metabolic perturbations. Methods and results: Three separate experiments were designed to quantify myocardial TG content: (1) over a 90-day period; (2) following a high-fat meal and (3) following a 48 hour fast. Proton spectra were collected from a 10 x 20 x 30mm voxel placed within the intraventricular septum, with measurements acquired at end-systole and end expiration, using cardiac triggering and respiratory gating. Minimal variation was observed between myocardial TG content determined 90 days apart (r = 0.98, cv = 5%), while TG values were unaffected by a high-fat meal despite a significant 2-fold increase (p < 0.05) in serum TG. In contrast, myocardial TG content increased 3-fold (p < 0.05) following a 48-hour fast, despite a 25% reduction in serum TG. Body mass index was significantly related to myocardial TG (r = 0.58, p< 0.05) and the change in myocardial TG following a 48 hour fast (r2 = 0.60). Conclusions:1H-MRS is a reliable method for the determination of myocardial TG in humans and relatively unaffected by the consumption of one high fat meal, but sensitive to changes following a prolonged fast.
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