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Am J Physiol Endocrinol Metab (May 28, 2002). doi:10.1152/ajpendo.00094.2001
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Articles in PresS, published online ahead of print May 28, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00094.2001
Submitted on March 5, 2001
Accepted on May 4, 2002

The intracranial administration of transforming growth factor-beta3 (TGF-ß3) increases fat oxidation in rats

Hanae Yamazaki1, Masanao Arai1, Shigenobu Matsumura1, Kazuo Inoue1, and Tohru Fushiki1*

1 Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Laboratory of Nutritional Chemistry, Kyoto, Kyoto, Japan

* To whom correspondence should be addressed. E-mail: d53765{at}sakura.kudpc.kyoto-u.ac.jp.

The effects of intracranial transforming growth factor (TGF)-ß3 on spontaneous motor activity and energy metabolism were examined in rats. After injection of TGF-ß3 into the cisterna magna of the rat, spontaneous motor activity decreased significantly for one hour. The intracranial injection of TGF-ß3 produced an immediate decrease in respiratory exchange ratio (RER). No significant changes were observed in energy expenditure. TGF-ß3 induced a significant increase in total fat oxidation and a decrease in total carbohydrate oxidation. Furthermore, the serum substrates associated with fat metabolism were significantly altered in rats injected with TGF-ß3. Both lipoprotein lipase activity in skeletal muscle and the concentration of serum ketone bodies increased, suggesting that the increase in fat oxidation caused by TGF-ß3 may have occurred in the liver and muscle. Intracranial injection of TGF-ß3 appeared to evoke a switch in the energy substrates accessed in energy expenditure. These results suggest that the release of TGF-ß3 in the brain by exercise is a signal for regulating energy consumption.




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