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Articles in PresS, published online ahead of print September 10, 2002
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00079.2002
Submitted on February 25, 2002
Accepted on September 5, 2002
1 Department of Endocrinology and Metabolism, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
2 Department of Biostatistics, Kyoto University School of Public Health, Kyoto, Japan
3 Third Department of Internal Medicine, Nihon University, Tokyo, Japan
* To whom correspondence should be addressed. E-mail: kikuchi{at}asahi-life.or.jp.
To characterize the "portal signal" in a non-steady hyperglycemic state, the kinetic relationship between net hepatic glucose balance (NHGB) and either hepatic glucose load (HGL) or plasma insulin level was determined during glucose infusion using a catheter technique in 36 conscious dogs. Glucose was infused intraportally (Po group) and peripherally (Pe group) at 39, 56 and 83 µmol.kg-1.min-1 over two hours. There was a linear relationship between mean NHGB and either mean HGL or plasma insulin levels at each rate in either delivery (HGL; Po: r=0.99, Pe: r=0.95 and insulin; Po: r=99, Pe: r=0.79). The threshold levels for net hepatic glucose uptake was 3.8 and 11.7 mmol.L-1 for plasma glucose, and 65 and 392 pmol.L-1 for plasma insulin, respectively. The slope of the regression line against the abscissa was 4 times larger in portal than in peripheral delivery (HGL; Po:0.20 vs Pe:0.05, p<0.05, insulin; Po: 0.19 vs Pe: 0.04, p<0.05). These results suggest that the portal signal overrules the threshold of glucose for hepatic uptake by increasing hepatic extraction rate in a non-steady hyperglycemic state.
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