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1 Biochemistry, University at Buffalo, State University of New York, Buffalo, New York, United States
* To whom correspondence should be addressed. E-mail: mspatel{at}buffalo.edu.
Chronic consumption of a high fat (HF) diet by female rats in their post-weaning period resulted in significant increases in body weight and plasma levels of insulin, glucose and triglycerides during pregnancy compared to female rats consuming a standard rodent laboratory chow (LC). On gestational day 21, plasma insulin levels and the insulin secretory response of islets to various secretogogues were significantly increased in HF fetuses. The HF male progeny weaned onto a standard rodent laboratory chowLC (HF/LC) demonstrated increases in body weight from postnatal day 60 onwards. In adulthood, HF/LC male rats were obesesignificantly heavier than controls, had increased plasma levels of insulin, glucose, free fatty acids and triglycerides and demonstrated glucose intolerance. HF/LC male islets secreted increased amounts of insulin in response to low glucose concentrations but their response to a high glucose concentration was bluntedsimilar to that of LC/LC islets. In another set of experiments, when the male progeny of HF female rats were weaned onto a high sucrose diet (HF/HSu) their metabolic profile was further worsened. These results indicate that chronic consumption of a high fata HF diet by female rats malprograms the male progeny for glucose intolerance and development of obesity increased body weight in adulthood. The long-term high fat feeding to female rats employed in this study bears resemblance to the dietary habits in Western societies. The results of this study implicate dietary practices of women in the etiology of the current epidemic of human obesity and related disorders.
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