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Articles in PresS, published online ahead of print November 20, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00078.2001
Submitted on March 2, 2001
Accepted on November 2, 2001
1 Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: bkiens{at}aki.ku.dk.
The resting content and the utilization of muscle triacylglycerol during 90 min of submaximal exercise (60% of peak oxygen uptake (VO2 peak)) were studied in twenty-one eumenorrheic female and twenty-one male subjects at different training levels (untrained (UT), moderately trained (MT), and endurance trained (END)). Males and females were matched according to their VO2 peak expressed relative to lean body mass (LBM), physical activity level and training history. All subjects ingested the same controlled diet for 8 days and all females were tested in the mid-follicular phase of the menstrual cycle. Resting myocellular triacylglycerol (MCTG), measured by means of the muscle biopsy technique, averaged 48.4±4.2, 48.5±8.4, and 52.2±5.8 mmol/kg dry weight (d.w.) in UT, MT, and END females, respectively, and 34.1±4.9, 31.6±3.3, and 38.4±3.0 mmol/kg d.w. in UT, MT, and END males, respectively (p<0.001, females versus males in all groups). Exercise decreased the content of MCTG in the female subjects by an average of 25%, irrespective of training status, whereas in the male groups the content of MCTG was unaffected by exercise. The arterial plasma concentration of insulin was higher (p<0.05), whereas the arterial plasma concentration of epinephrine was lower (p<0.05) in the females than in the males at rest and during exercise. MCTG utilization was correlated to the resting concentration of MCTG (p<0.001). It is concluded that resting content and utilization of MCTG during exercise are related to gender and, furthermore, are independent of training status.
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