Diet-induced obesity and hepatic gene expression alteration in C57BL/6J and ICAM-1 deficient mice

doi:10.1152/ajpendo.00072.2001

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Am J Physiol Endocrinol Metab (October 2, 2001). doi:10.1152/ajpendo.00072.2001

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Articles in PresS, published online ahead of print October 2, 2001
Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00072.2001
Submitted on February 28, 2001
Accepted on September 26, 2001

Diet-induced obesity and hepatic gene expression alteration in C57BL/6J and ICAM-1 deficient mice

Francine M Gregoire^*, Qin Zhang, Steven J Smith, Carmen Tong, David Ross, Henry Lopez, and David B West

^* To whom correspondence should be addressed. E-mail: fmgregoire{at}metabolex.com.

The effects of high-fat feeding on the development of obesity were evaluated in ICAM-1 knockout and C57BL/6J (B6) male mice fed a high-fat diet for up to 50 days. Serum and tissues were collected at baseline, and after 1, 11, and 50 days on diet. After 11 days on diet, ICAM-1 deficient, but not B6 mice, developed fatty livers and showed a significant increase in inguinal fat pad weight. At day 50, ICAM-1-deficient mice weighed less and their adiposity index and circulating leptin levels were significantly lower than B6 controls. To better understand the early differential response to the diet, liver gene expression was analyzed at three time points using Affymetrix GeneChips®. In both strains, a similar pattern of gene expression was detected in response to high-fat diet. However, SREBP-1, ApoA4 and adipsin mRNAs were significantly induced in ICAM-1-deficient livers, suggesting that these genes and their associated pathways may be involved in the acute diet-response observed in the knockout mice.

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