| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Pharmacology, New York Medical College, Valhalla, New York, USA
2 Department of Pathology, New York Medical College, Valhalla, New York, USA
* To whom correspondence should be addressed. E-mail: charles_stier{at}nymc.edu.
Estrogen produces both beneficial and adverse effects on cardiovascular health via mechanisms that remain unclear. Stroke-prone spontaneously hypertensive rats (SHRSP) maintained on Stroke-Prone Rodent Diet and 1% NaCl drinking water (starting at 8 weeks of age) rapidly develop stroke and malignant nephrosclerosis that can be prevented despite continued hypertension by drugs targeting angiotensin II and aldosterone actions. This study evaluated estrogen's effects in the above SHRSP model. Female SHRSP that were shamoperated (SHAM), ovariectomized (OVX) at 4 weeks of age, or OVX and treated with estradiol benzoate (E2, 30 µg/kg per week) were studied. In a survival protocol, OVX rats lived significantly longer (15.1 ± 0.3 weeks) compared to SHAM (13.6 ± 0.2 weeks) or OVX+E2 rats (12.4 ± 0.2 weeks). In a protocol in which animals were matched for age, 11.5 weeks, terminal systolic blood pressure and urine protein excretion were elevated in SHAM and OVX+E2 rats compared to OVX rats; blood urea nitrogen, renal microvascular and glomerular lesions, and plasma renin concentration were elevated in OVX+E2 relative to SHAM or OVX rats. In a survival protocol using intact female SHRSP, treatment with an antiestrogen (tamoxifen, 7 mg/kg per week) prolonged survival by more than two weeks compared with controls (P < 0.01). The data indicate that estrogen promotes microangiopathy in the kidney and stroke in salinedrinking SHRSP.
This article has been cited by other articles:
|
|
 |
|
  C. Baylis Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency Physiology, June 1, 2008; 23(3): 142 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Rigsby, A. E. Burch, S. Ogbi, D. M. Pollock, and A. M. Dorrance Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1754 - R1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rodriguez-Porcel, X.-Y. Zhu, A. R. Chade, B. Amores-Arriaga, N. M. Caplice, E. L. Ritman, A. Lerman, and L. O. Lerman Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H978 - H984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tsuda, I. Nishio, T. Kurth, and J. E. Buring Smoking, Estrogen, and Membrane Microviscosity in Women * Response Stroke, April 1, 2004; 35(4): e71 - e71. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
